Description: Recent Advances in Glucocorticoid Receptor Action, Hardcover by Cato, A.; Schaecke, H.; Asadullah, K., ISBN 3540432299, ISBN-13 9783540432296, Brand New, Free shipping in the US Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar macological concentrations for the suppression of clinical manifesta tions of rheumatoid arthritis. Numerous compounds with GC activity have also been developed and used. Fifty years after their initial clinical use, GCs are still the most im portant and frequently prescribed class of anti-inflammatory drugs for various inflammatory disorders. They are administered either orally, parenterally (intravenous, intramuscular, intrathecal), or topically (cu taneous, intranasal, pulmonic, rectal). Despite the many beneficial ef fects of GCs, they also have their limitations and disadvantages that occur with varying prevalence on different organs and after different durations of therapy. These side-effects can range in severity from cos metic (. telangiectasias, hypertrichosis) to seriously disabling (. induction of glaucoma, diabetes, osteoporosis) or even life-threatening disorders (. gastric haemorrhage). These adverse effects of GCs se riously handicap their successful use as anti-inflammatory agents. There is therefore a strong need for the development of substances with the anti-inflammatory potency of classical GCs but with reduced side-effects.
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Book Title: Recent Advances in Glucocorticoid Receptor Action
Number of Pages: Xxi, 380 Pages
Language: English
Publication Name: Recent Advances in Glucocorticoid Receptor Action
Publisher: Springer Berlin / Heidelberg
Publication Year: 2002
Subject: Life Sciences / Biochemistry, Endocrinology & Metabolism, Pharmacology
Item Weight: 28.7 Oz
Type: Textbook
Subject Area: Science, Medical
Item Length: 8.8 in
Author: H. Schaecke
Item Width: 6 in
Series: Ernst Schering Foundation Symposium Proceedings Ser.
Format: Hardcover
