Recent Advances in Glucocorticoid Receptor Action by A. Cato (English) Hardcover

Description: Recent Advances in Glucocorticoid Receptor Action by A. Cato, H. Schaecke, K. Asadullah Provides an in-depth overview of the molecular actions of the glucocorticoid receptor and discusses the chances of an imminent identification of selective glucocorticoid agonists. Such componds should fulfill all the criteria of a glucocorticoid but should lack the side effects. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description The long-term use of glucocorticoids is associated with several deleterious effects. Attempts to separate the beneficial from the adverse effects of these compounds have met with varying degrees of difficulty. The discovery of distinct modes of action of the glucocorticoid receptor, the protein that mediates glucocorticoid action has opened up many possibilities for improving glucocorticoid therapy. This book provides an in-depth overview of the molecular actions of the glucocorticoid receptor and discusses the chances of an imminent identification of selective glucocorticoid agonists. Such componds should fulfill all the criteria of a glucocorticoid but should lack the sideeffects so far linked with classical glucocorticoids. Table of Contents 1 Glucocorticoids and Asthma.- 2 Immune Monitoring of Glucocorticoid Therapy.- 3 Topical Glucocorticoid Therapy in Dermatology.- 4 Bone Effects of Glucocorticoid Therapy.- 5 Corticosteroids in Ophthalmology.- 6 Special Problems in Glucocorticoid Treatment in Children.- 7 Functional Implications of Glucocorticoid Receptor Trafficking.- 8 The Dynamics of Intranuclear Movement and Chromatin Remodeling by the Glucocorticoid Receptor.- 9 Glucocorticoid Receptor Antagonism of AP-1 Activity by Inhibition of MAPK Family.- 10 Mast Cells as Targets for Glucocorticoids in the Treatment of Allergic Disorders.- 11 Cytosolic Glucocorticoid Receptor-Interacting Proteins.- 12 The Glucocorticoid Receptor ?-Isoform: A Perspective on Its Relevance in Human Health and Disease.- 13 Cooperation of Nuclear Transcription Factors Regulated by Steroid and Peptide Hormones.- 14 Induction and Repression of NF-?B-Driven Inflammatory Genes.- 15 DNA-Dependent Cofactor Selectivity of the Glucocorticoid Receptor.- 16 The Anti-inflammatory Action of Glucocorticoid Hormones.- 17 Analysis of Glucocorticoid Receptor Function in the Mouse by Gene Targeting.- 18 Glucocorticoid-Inducible Genes That Regulate T-Cell Function.- 19 Structural Analysis of the GR Ligand-Binding Domain.- 20 SEGRAs: A Novel Class of Anti-inflammatory Compounds.- Previous Volumes Published in This Series. Long Description Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar Details ISBN3540432299 Short Title RECENT ADVANCES IN GLUCOCORTIC Language English ISBN-10 3540432299 ISBN-13 9783540432296 Media Book Format Hardcover Series Number 40 Year 2002 Publication Date 2002-09-12 Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany Pages 380 Edition 2002nd Edited by K. Asadullah DOI 10.1007/b83267;10.1007/978-3-662-04660-9 Author K. Asadullah Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Edition Description 2002 ed. Series Ernst Schering Foundation Symposium Proceedings Alternative 9783662046623 DEWEY 615.364 Audience Professional & Vocational Illustrations 12 Illustrations, color; 56 Illustrations, black and white; XXI, 380 p. 68 illus., 12 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:158422581;

Price: 518.03 AUD

Location: Melbourne

End Time: 2025-01-11T18:15:36.000Z

Shipping Cost: N/A AUD